报告题目：Energetic Footprint of Cortical Function 

　　报告人：D. S. FAHMEED HYDER, Ph.D. 

　        　Professor, Biomedical Engineering (seas.yale.edu) 

　        　Professor, Diagnostic Radiology (bioimaging.yale.edu) 

　　        Technical Director, Magnetic Resonance Research Center (mrrc.yale.edu) 

　        　Program Director, Quantitative Neuroscience withMagnetic Resonance (qnmr.yale.edu) 

　        　Yale University, New Haven, CT, USA 

　　邀请人：徐富强研究员 

　　报告日期：2014年3月14日，周五上午10点 

　　报告地点：波谱楼二楼会议室 

　　报告摘要： 

　　Energy demand of neural activity in cerebral cortex is extraordinarily high, a necessity met by glucose oxidation yielding ATPabundantly. My narrative trails through folklore and dogma to discoveries from various independent observations about how brain’s insatiable appetite for glucose and oxygen dynamicallytracks neural activity, from regions as small as cortical columns to large cortical swathes across hemispheres. Results show that imaging oxidative energy provides anintegrated perspective on brain networks, where oxidative energy demand of cortical workspace is quite uniform. Diagnosis of brain disorders and diseases can be improved by mapping the oxidative energetic footprint of cortical function. 

　　报告人简介：  

　　The societal burden of misdiagnosed brain disorders and diseases is substantial. The Hyder lab is leading breakthroughs in quantitative and translational imaging technologies, based primarily on magnetic resonance methods, to visualize molecular processes of function and dysfunction at the laminar level. A primary interest of the Hyder lab is to develop functional imaging techniques that relate neural activity to underlying laminar structure in health and disease. Emphasis is on fMRI, but other multi-modal fMRI methods in conjunction with MRS, electrophysiology, optical imaging, and PET are being sought for increased biomarker specificity. Another active interest in the Hyder lab is molecular imaging with magnetic resonance technologies where several disciplines connect, from chemistry and physics to material science and physiology. A new molecular imaging method, pioneered in the Hyder lab called BIRDS, combines high MRI spatial resolution with high MRS molecular specificity.  

　　Hyder is a director of high-field horizontal small-bore systems at Yale’s MRRC, one of the most reputed in vivo magnetic resonance centers in the world conducting translational in vivo neuroscience and metabolism research. He is also founder and director of Yale’s QNMR Core Center, the only NIH-supported programmatic effort at Yale on neuroimaging with magnetic resonance technologies. Prof. Hyder received his bachelor’s degree in physical chemistry in 1990 from Wabash and the doctoral degree in biophysical chemistry from Yale in 1995. He has been a faculty at Yale since 1999 and currently holds dual professor appointments in Diagnostic Radiology and Biomedical Engineering. Prof. Hyder is one of the founding members of Yale’s Department of Biomedical Engineering. His work has produced over a hundred peer-reviewed publications, and written and edited books on functional brain imaging. He also holds several magnetic resonance patents on molecular imaging. He has had continuous NIH support since becoming an investigator, and also renewed grants from different scientific funding agencies. He has received early career awards from various scientific societies and funding agencies. He sits on editorial boards of several international scientific journals, and reviews for many scientific journals spanning several disciplines. He has delivered numerous invited presentations around the globe, and serves on advisory panels of several scientific funding agencies.